2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N12486A
    (3S,8R,9R)-Isofalcarintriol 2962060-53-1 98%
    (3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging.
    (3S,8R,9R)-Isofalcarintriol
  • HY-P10737A
    CGGK acetate
    CGGK acetate is a control peptide of CAQK peptide (HY-P10216).
    CGGK acetate
  • HY-P991046
    Donanemab (Mouse IgG2b) 98%
    Donanemab (Mouse IgG2b) is an anti-amyloid inhibitory antibody with Mouse IgG2b. Donanemab can be used in research about Alzheimer's disease.
    Donanemab (Mouse IgG2b)
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3 99.65%
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline-d3
  • HY-U00123A
    Guanoxabenz hydrochloride 23256-40-8 99.72%
    Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor.
    Guanoxabenz hydrochloride
  • HY-W000665
    2,6-Dimethyl-L-tyrosine 123715-02-6 99.94%
    2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides.
    2,6-Dimethyl-L-tyrosine
  • HY-W001692
    Ocinaplon 96604-21-6 99.70%
    Ocinaplon (DOV 273547) is a partial GABAA receptor positive allosteric modulator with relatively high efficacy at the α1 subunit.
    Ocinaplon
  • HY-W004425
    DMPX 14114-46-6 98%
    DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penetrable caffeine analogue. DMPX is A2 selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists such as NECA (HY-103173). DMPX can be used in the study of Parkinson's disease and other diseases.
    DMPX
  • HY-W005749
    (R)-4-Amino-3-hydroxybutyric acid 7013-07-2
    (R)-4-Amino-3-hydroxybutyric acid ((R)-GABOB) is a 4-aminobutyric acids (GABAB) agonist. (R)-4-Amino-3-hydroxybutyric acid is promising for research of nervous disorders.
    (R)-4-Amino-3-hydroxybutyric acid
  • HY-W008610
    GBR 12783 67469-57-2 98%
    GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats.
    GBR 12783
  • HY-W008645
    NCS-382 sodium 131733-92-1 ≥99.0%
    NCS-382 (sodium) is a potent GABA receptor antagonist. NCS-382 (sodium) has anti-sedative and anti-hypnotic activities and can be used in research related to neurological diseases.
    NCS-382 sodium
  • HY-W009267
    2-Amino-5-bromo-2′-fluorobenzophenone 1479-58-9 98%
    2-Amino-5-bromo-2′-fluorobenzophenone is a precursor in the synthesis of Flubromazepam.
    2-Amino-5-bromo-2′-fluorobenzophenone
  • HY-W009754
    Antidepressant agent 10 87691-87-0 99.96%
    Antidepressant agent 10 (Compound 4) is an orally active compound. Antidepressant agent 10 has IC50 values of 190 nM and 110 nM for 5-HT1A and 5-HT2, respectively. Antidepressant agent 10 can be used in the research of mental disorders.
    Antidepressant agent 10
  • HY-W016591
    2,4-Diisopropylphenol 2934-05-6
    2,4-Diisopropylphenol is a widely accepted chemical agent.
    2,4-Diisopropylphenol
  • HY-W017500
    N-Methyl-DL-aspartic acid 17833-53-3 ≥98.0%
    N-Methyl-DL-aspartic acid is a glutamate analogue and a NMDA receptor agonist and can be used for neurological diseases research.
    N-Methyl-DL-aspartic acid
  • HY-W056439
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine 224779-27-5 98%
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can increase the activity of β-glucocerebrosidase by 20%. N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can be used in the study of lysosomal storage diseases and other protein storage diseases.
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
  • HY-W070306
    PDK1-IN-1 1207836-10-9
    PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor, and can be used for research of myeloproliferative disorders or cancer.
    PDK1-IN-1
  • HY-W077226
    AChE-IN-23 6297-14-9 99.49%
    AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 48.3 μM.
    AChE-IN-23
  • HY-W077477
    IHCH-7113 313368-85-3 98%
    IHCH-7113 (Compound 166) is an agonist of 5-HT2A serotonin receptor with antidepressant activity. IHCH-7113 is promising for research of antipsychotic agent.
    IHCH-7113
  • HY-W089856
    Chlorobutanol hemihydrate 6001-64-5 ≥98.0%
    Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries.
    Chlorobutanol hemihydrate
Cat. No. Product Name / Synonyms Application Reactivity